matlab simbiology model Search Results


odyssey imaging system  (LI-COR)
99
LI-COR odyssey imaging system
Odyssey Imaging System, supplied by LI-COR, used in various techniques. Bioz Stars score: 99/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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matlab simbiology  (MathWorks Inc)
97
MathWorks Inc matlab simbiology
Matlab Simbiology, supplied by MathWorks Inc, used in various techniques. Bioz Stars score: 97/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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matlab r2017b  (MathWorks Inc)
96
MathWorks Inc matlab r2017b
Fig. 2. Simplified diagram for the semi-PBPK model of maribavir disposition in cynomolgus monkeys. Numbers in the graph denote physiologic and biologic pro- cesses: (1) transit of substance from stomach to duodenum; (2) transit within the small intestine; (3) transit within the colon and to feces; (4) absorption from the small intestine; (5) conversion of glucuronides to parent, which occurs in the last two compartments of the ileal lumen and throughout the colon; (6) absorption from the colon; (7) biliary excretion of parent; (8) glucuronidation of parent and secretion to duodenal lumen; (9) excretion of glucuronides in urine; (10) transport between the liver and central compartment; (11) transport between the central and peripheral compartments; (12) renal excretion of parent; and (13) all other pathways for parent. The two segments of the jejunum, four segments of the ileum, and five of the colon were not separately depicted in this diagram; the detailed diagram in <t>MATLAB</t> SimBiology is shown in Supplemental Fig. 1. MBV, maribavir (parent); MBV-Gluc, maribavir glucuronides; Met, other metabolites of maribavir.
Matlab R2017b, supplied by MathWorks Inc, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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matlab 17b  (MathWorks Inc)
96
MathWorks Inc matlab 17b
Fig. 2. Simplified diagram for the semi-PBPK model of maribavir disposition in cynomolgus monkeys. Numbers in the graph denote physiologic and biologic pro- cesses: (1) transit of substance from stomach to duodenum; (2) transit within the small intestine; (3) transit within the colon and to feces; (4) absorption from the small intestine; (5) conversion of glucuronides to parent, which occurs in the last two compartments of the ileal lumen and throughout the colon; (6) absorption from the colon; (7) biliary excretion of parent; (8) glucuronidation of parent and secretion to duodenal lumen; (9) excretion of glucuronides in urine; (10) transport between the liver and central compartment; (11) transport between the central and peripheral compartments; (12) renal excretion of parent; and (13) all other pathways for parent. The two segments of the jejunum, four segments of the ileum, and five of the colon were not separately depicted in this diagram; the detailed diagram in <t>MATLAB</t> SimBiology is shown in Supplemental Fig. 1. MBV, maribavir (parent); MBV-Gluc, maribavir glucuronides; Met, other metabolites of maribavir.
Matlab 17b, supplied by MathWorks Inc, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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compartment pk pd model  (MathWorks Inc)
94
MathWorks Inc compartment pk pd model
Fig. 2. Simplified diagram for the semi-PBPK model of maribavir disposition in cynomolgus monkeys. Numbers in the graph denote physiologic and biologic pro- cesses: (1) transit of substance from stomach to duodenum; (2) transit within the small intestine; (3) transit within the colon and to feces; (4) absorption from the small intestine; (5) conversion of glucuronides to parent, which occurs in the last two compartments of the ileal lumen and throughout the colon; (6) absorption from the colon; (7) biliary excretion of parent; (8) glucuronidation of parent and secretion to duodenal lumen; (9) excretion of glucuronides in urine; (10) transport between the liver and central compartment; (11) transport between the central and peripheral compartments; (12) renal excretion of parent; and (13) all other pathways for parent. The two segments of the jejunum, four segments of the ileum, and five of the colon were not separately depicted in this diagram; the detailed diagram in <t>MATLAB</t> SimBiology is shown in Supplemental Fig. 1. MBV, maribavir (parent); MBV-Gluc, maribavir glucuronides; Met, other metabolites of maribavir.
Compartment Pk Pd Model, supplied by MathWorks Inc, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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jmp 11  (SAS institute)
90
SAS institute jmp 11
Fig. 2. Simplified diagram for the semi-PBPK model of maribavir disposition in cynomolgus monkeys. Numbers in the graph denote physiologic and biologic pro- cesses: (1) transit of substance from stomach to duodenum; (2) transit within the small intestine; (3) transit within the colon and to feces; (4) absorption from the small intestine; (5) conversion of glucuronides to parent, which occurs in the last two compartments of the ileal lumen and throughout the colon; (6) absorption from the colon; (7) biliary excretion of parent; (8) glucuronidation of parent and secretion to duodenal lumen; (9) excretion of glucuronides in urine; (10) transport between the liver and central compartment; (11) transport between the central and peripheral compartments; (12) renal excretion of parent; and (13) all other pathways for parent. The two segments of the jejunum, four segments of the ileum, and five of the colon were not separately depicted in this diagram; the detailed diagram in <t>MATLAB</t> SimBiology is shown in Supplemental Fig. 1. MBV, maribavir (parent); MBV-Gluc, maribavir glucuronides; Met, other metabolites of maribavir.
Jmp 11, supplied by SAS institute, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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iqm tools  (IntiQuan GmbH)
90
IntiQuan GmbH iqm tools
Fig. 2. Simplified diagram for the semi-PBPK model of maribavir disposition in cynomolgus monkeys. Numbers in the graph denote physiologic and biologic pro- cesses: (1) transit of substance from stomach to duodenum; (2) transit within the small intestine; (3) transit within the colon and to feces; (4) absorption from the small intestine; (5) conversion of glucuronides to parent, which occurs in the last two compartments of the ileal lumen and throughout the colon; (6) absorption from the colon; (7) biliary excretion of parent; (8) glucuronidation of parent and secretion to duodenal lumen; (9) excretion of glucuronides in urine; (10) transport between the liver and central compartment; (11) transport between the central and peripheral compartments; (12) renal excretion of parent; and (13) all other pathways for parent. The two segments of the jejunum, four segments of the ileum, and five of the colon were not separately depicted in this diagram; the detailed diagram in <t>MATLAB</t> SimBiology is shown in Supplemental Fig. 1. MBV, maribavir (parent); MBV-Gluc, maribavir glucuronides; Met, other metabolites of maribavir.
Iqm Tools, supplied by IntiQuan GmbH, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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phoenix winnonlin  (Certara L.P)
86
Certara L.P phoenix winnonlin
Fig. 2. Simplified diagram for the semi-PBPK model of maribavir disposition in cynomolgus monkeys. Numbers in the graph denote physiologic and biologic pro- cesses: (1) transit of substance from stomach to duodenum; (2) transit within the small intestine; (3) transit within the colon and to feces; (4) absorption from the small intestine; (5) conversion of glucuronides to parent, which occurs in the last two compartments of the ileal lumen and throughout the colon; (6) absorption from the colon; (7) biliary excretion of parent; (8) glucuronidation of parent and secretion to duodenal lumen; (9) excretion of glucuronides in urine; (10) transport between the liver and central compartment; (11) transport between the central and peripheral compartments; (12) renal excretion of parent; and (13) all other pathways for parent. The two segments of the jejunum, four segments of the ileum, and five of the colon were not separately depicted in this diagram; the detailed diagram in <t>MATLAB</t> SimBiology is shown in Supplemental Fig. 1. MBV, maribavir (parent); MBV-Gluc, maribavir glucuronides; Met, other metabolites of maribavir.
Phoenix Winnonlin, supplied by Certara L.P, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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symbolic math  (MathWorks Inc)
94
MathWorks Inc symbolic math
Fig. 2. Simplified diagram for the semi-PBPK model of maribavir disposition in cynomolgus monkeys. Numbers in the graph denote physiologic and biologic pro- cesses: (1) transit of substance from stomach to duodenum; (2) transit within the small intestine; (3) transit within the colon and to feces; (4) absorption from the small intestine; (5) conversion of glucuronides to parent, which occurs in the last two compartments of the ileal lumen and throughout the colon; (6) absorption from the colon; (7) biliary excretion of parent; (8) glucuronidation of parent and secretion to duodenal lumen; (9) excretion of glucuronides in urine; (10) transport between the liver and central compartment; (11) transport between the central and peripheral compartments; (12) renal excretion of parent; and (13) all other pathways for parent. The two segments of the jejunum, four segments of the ileum, and five of the colon were not separately depicted in this diagram; the detailed diagram in <t>MATLAB</t> SimBiology is shown in Supplemental Fig. 1. MBV, maribavir (parent); MBV-Gluc, maribavir glucuronides; Met, other metabolites of maribavir.
Symbolic Math, supplied by MathWorks Inc, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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global optimization toolbox version 3 4  (MathWorks Inc)
97
MathWorks Inc global optimization toolbox version 3 4
Fig. 2. Simplified diagram for the semi-PBPK model of maribavir disposition in cynomolgus monkeys. Numbers in the graph denote physiologic and biologic pro- cesses: (1) transit of substance from stomach to duodenum; (2) transit within the small intestine; (3) transit within the colon and to feces; (4) absorption from the small intestine; (5) conversion of glucuronides to parent, which occurs in the last two compartments of the ileal lumen and throughout the colon; (6) absorption from the colon; (7) biliary excretion of parent; (8) glucuronidation of parent and secretion to duodenal lumen; (9) excretion of glucuronides in urine; (10) transport between the liver and central compartment; (11) transport between the central and peripheral compartments; (12) renal excretion of parent; and (13) all other pathways for parent. The two segments of the jejunum, four segments of the ileum, and five of the colon were not separately depicted in this diagram; the detailed diagram in <t>MATLAB</t> SimBiology is shown in Supplemental Fig. 1. MBV, maribavir (parent); MBV-Gluc, maribavir glucuronides; Met, other metabolites of maribavir.
Global Optimization Toolbox Version 3 4, supplied by MathWorks Inc, used in various techniques. Bioz Stars score: 97/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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odyssey  (LI-COR)
99
LI-COR odyssey
Fig. 2. Simplified diagram for the semi-PBPK model of maribavir disposition in cynomolgus monkeys. Numbers in the graph denote physiologic and biologic pro- cesses: (1) transit of substance from stomach to duodenum; (2) transit within the small intestine; (3) transit within the colon and to feces; (4) absorption from the small intestine; (5) conversion of glucuronides to parent, which occurs in the last two compartments of the ileal lumen and throughout the colon; (6) absorption from the colon; (7) biliary excretion of parent; (8) glucuronidation of parent and secretion to duodenal lumen; (9) excretion of glucuronides in urine; (10) transport between the liver and central compartment; (11) transport between the central and peripheral compartments; (12) renal excretion of parent; and (13) all other pathways for parent. The two segments of the jejunum, four segments of the ileum, and five of the colon were not separately depicted in this diagram; the detailed diagram in <t>MATLAB</t> SimBiology is shown in Supplemental Fig. 1. MBV, maribavir (parent); MBV-Gluc, maribavir glucuronides; Met, other metabolites of maribavir.
Odyssey, supplied by LI-COR, used in various techniques. Bioz Stars score: 99/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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rrid scr 008394 insight toolkit itk insight software consortium  (Dotmatics Limited)
86
Dotmatics Limited rrid scr 008394 insight toolkit itk insight software consortium
Fig. 2. Simplified diagram for the semi-PBPK model of maribavir disposition in cynomolgus monkeys. Numbers in the graph denote physiologic and biologic pro- cesses: (1) transit of substance from stomach to duodenum; (2) transit within the small intestine; (3) transit within the colon and to feces; (4) absorption from the small intestine; (5) conversion of glucuronides to parent, which occurs in the last two compartments of the ileal lumen and throughout the colon; (6) absorption from the colon; (7) biliary excretion of parent; (8) glucuronidation of parent and secretion to duodenal lumen; (9) excretion of glucuronides in urine; (10) transport between the liver and central compartment; (11) transport between the central and peripheral compartments; (12) renal excretion of parent; and (13) all other pathways for parent. The two segments of the jejunum, four segments of the ileum, and five of the colon were not separately depicted in this diagram; the detailed diagram in <t>MATLAB</t> SimBiology is shown in Supplemental Fig. 1. MBV, maribavir (parent); MBV-Gluc, maribavir glucuronides; Met, other metabolites of maribavir.
Rrid Scr 008394 Insight Toolkit Itk Insight Software Consortium, supplied by Dotmatics Limited, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Image Search Results


Fig. 2. Simplified diagram for the semi-PBPK model of maribavir disposition in cynomolgus monkeys. Numbers in the graph denote physiologic and biologic pro- cesses: (1) transit of substance from stomach to duodenum; (2) transit within the small intestine; (3) transit within the colon and to feces; (4) absorption from the small intestine; (5) conversion of glucuronides to parent, which occurs in the last two compartments of the ileal lumen and throughout the colon; (6) absorption from the colon; (7) biliary excretion of parent; (8) glucuronidation of parent and secretion to duodenal lumen; (9) excretion of glucuronides in urine; (10) transport between the liver and central compartment; (11) transport between the central and peripheral compartments; (12) renal excretion of parent; and (13) all other pathways for parent. The two segments of the jejunum, four segments of the ileum, and five of the colon were not separately depicted in this diagram; the detailed diagram in MATLAB SimBiology is shown in Supplemental Fig. 1. MBV, maribavir (parent); MBV-Gluc, maribavir glucuronides; Met, other metabolites of maribavir.

Journal: Drug metabolism and disposition: the biological fate of chemicals

Article Title: Elucidation of Metabolic and Disposition Pathways for Maribavir in Nonhuman Primates through Mass Balance and Semi-Physiologically Based Modeling Approaches.

doi: 10.1124/dmd.121.000493

Figure Lengend Snippet: Fig. 2. Simplified diagram for the semi-PBPK model of maribavir disposition in cynomolgus monkeys. Numbers in the graph denote physiologic and biologic pro- cesses: (1) transit of substance from stomach to duodenum; (2) transit within the small intestine; (3) transit within the colon and to feces; (4) absorption from the small intestine; (5) conversion of glucuronides to parent, which occurs in the last two compartments of the ileal lumen and throughout the colon; (6) absorption from the colon; (7) biliary excretion of parent; (8) glucuronidation of parent and secretion to duodenal lumen; (9) excretion of glucuronides in urine; (10) transport between the liver and central compartment; (11) transport between the central and peripheral compartments; (12) renal excretion of parent; and (13) all other pathways for parent. The two segments of the jejunum, four segments of the ileum, and five of the colon were not separately depicted in this diagram; the detailed diagram in MATLAB SimBiology is shown in Supplemental Fig. 1. MBV, maribavir (parent); MBV-Gluc, maribavir glucuronides; Met, other metabolites of maribavir.

Article Snippet: The model construction, parameter estimation, simulations, and sensitivity analyses were conducted with SimBiology version 5.7 hosted in MATLAB R2017b with Optimization Toolbox version 8.0 (The Mathworks Inc., Natick, MA).

Techniques:

Fig. 6. Observed plasma concentration vs. time profiles of maribavir in cynomolgus monkey overlaid with fitted curves [BDC only (A)] or simulations [intact animals (B, C, D, and E)] in MATLAB SimBiology. (A) Observed data in individual BDC animals overlaid with fitted curve; (B) simulated data with a single intravenous administration in intact animals, using fm(Gluc) at 0.728 or 0.853 at both 5-mg/kg and 13-mg/kg doses, overlaid with individually observed data; (C) simulated data with a single p.o. administration in intact animals, using fm(Gluc) at 0.728 at 10-mg/kg dose, overlaid with individually observed data; (D) simulated data with repeated b.i.d. p.o. administration at 10, 30, or 100 mg/kg in intact male animals within the first 8 hours on day 2, using fm(Gluc) at 0.728, overlaid with individually observed data (Koszalka et al., 2002); (E) simulated data with repeated b.i.d. p.o. administrations at 10, 30, or 100 mg/kg in intact male animals within the first 8 hours on day 27, using fm(Gluc) at 0.728, overlaid with individually observed data (Koszalka et al., 2002).

Journal: Drug metabolism and disposition: the biological fate of chemicals

Article Title: Elucidation of Metabolic and Disposition Pathways for Maribavir in Nonhuman Primates through Mass Balance and Semi-Physiologically Based Modeling Approaches.

doi: 10.1124/dmd.121.000493

Figure Lengend Snippet: Fig. 6. Observed plasma concentration vs. time profiles of maribavir in cynomolgus monkey overlaid with fitted curves [BDC only (A)] or simulations [intact animals (B, C, D, and E)] in MATLAB SimBiology. (A) Observed data in individual BDC animals overlaid with fitted curve; (B) simulated data with a single intravenous administration in intact animals, using fm(Gluc) at 0.728 or 0.853 at both 5-mg/kg and 13-mg/kg doses, overlaid with individually observed data; (C) simulated data with a single p.o. administration in intact animals, using fm(Gluc) at 0.728 at 10-mg/kg dose, overlaid with individually observed data; (D) simulated data with repeated b.i.d. p.o. administration at 10, 30, or 100 mg/kg in intact male animals within the first 8 hours on day 2, using fm(Gluc) at 0.728, overlaid with individually observed data (Koszalka et al., 2002); (E) simulated data with repeated b.i.d. p.o. administrations at 10, 30, or 100 mg/kg in intact male animals within the first 8 hours on day 27, using fm(Gluc) at 0.728, overlaid with individually observed data (Koszalka et al., 2002).

Article Snippet: The model construction, parameter estimation, simulations, and sensitivity analyses were conducted with SimBiology version 5.7 hosted in MATLAB R2017b with Optimization Toolbox version 8.0 (The Mathworks Inc., Natick, MA).

Techniques: Clinical Proteomics, Concentration Assay